【摘要】 通过214例流行性出血热患者血清与尿液β₂-微球蛋白（β₂-MG）的动态检测,表明发病早期其血β₂-MG。即高达6.85±2.2mg/L,随肾功能损害的出现,血与尿β₂-MG均显著增高（分别为16.9±3.4和12.7±5.1mg/L）。尿β₂-MG≥20mg/L者临床预后欠佳。当肾功能明显改善后,尿β₂-MG显著降低（3.0±1.1mg/L）。随访23例,结果21.7％血β₂-MG持续异常,提示仍有肾功能不全。用于流行性出血热早期诊断,临床监测和判断预后等β₂-MG优于BUN和Cr。更多还原

【Abstract】 Sequential determination of serum and urine β₂-microglobulin （β₂-MG）, blood urea nitrogen （BUN） and serm creatinine（Cr）were carried out in two hundred and fourfeen cases of epidemic hem- orrhagic fiver （EHF）of different phases. The results showed that the levels of serum and urine β₂-MG were closely correlated with serum BUN and Cr in EHF patients. But the serum and urine β₂-MG was more sensitive than blood BUN and Cr in reflecting the functional state of the kidneys. It was found that the differences in the value of serum β₂-MG in mild,modeuately seveue,severe,and eritical cases were statistically significant（p<0.01）,but the differences in urine β₂-MG valre among patients with EHF of variors phases were less significant. These results indicated that the elevation of serum β₂-MG value was parallel to the severity of injurt to the kidneys.更多还原