【摘要】 本文报告应用新的转换酶抑制剂依那普利(enalapril)治疗59例原发性高血压的临床疗效。采甩随机单盲及双盲法进行,对照药为巯甲丙脯酸。结果表明:依那普利使收缩压及舒张压均降低10％以上(由21.5±1.6/13.8±0.9kPa降至19.2±2.2/12.3±1.0kPa),总有效率为74.2％,与巯甲丙脯酸相仿,但前者作用持续时间显著延长。半数患者的有效剂量为10mg/d,80％在20mg/d以下。本药对血像、肝肾功能、血电解质及糖、脂类代谢未见明显影响。更多还原

【Abstract】 Fifty nine patients with essential hypertension were treated with angiotensin converting enzyme inhibitor—enalapril and captopril by random and double blind method. The results showed that enalapril and captopril could reduce the systolic and diastolic blood pressure signi- ficantly (from 21.5±1.6/13.8±0. 9 kPa to 19.2±2.2/12.3±1.0 kPa and 21.9±2.4/l3.6±0.9 kPa to 19.7±2.3/l2.1 ± 1.1 kPa, P<0.05,respectively). The hypotensive action of enalapril was longer than that of captopril. The effective dosage of enalapril was l0-20mg/d. No significant adverse effect to the liver and kidney function, levels of serum electrolytes, blood glucose and lipids, and blood cell count was observed.更多还原