【摘要】 用ADP引起兔血小板脱敏,测定血小板上ADP受体的K_D及数目,并与正常血小板上的数据比较。正常血小板的K~D=0.0129nM,受体数=857.69;而脱敏血小扳的K′_D=0.0265nM,受体数=294.78。以上结果说明由于细胞表面受体的内化,使受体亲和力及受体数目减少。更多还原

【Abstract】 By using ADP desensitized rabbit platelets, the determination of KD and ADP receptor numbers in desensitized platelets were investigated, and compared with that of normal ones. In normal platelets, KD = 0.0129nM, number of receptors = 857.69; while in desensitized platelets, KD = 0.0265 nM, number of receptors= 294.78. these results indicate that desensitization leads to a reduction in receptor affinity and receptor number due to interaalization of cell surface receptors.更多还原