【摘要】 <正> LAK细胞过继免疫疗法中的抗肿瘤抗转移作用已在动物实验中证实并已应用于临床。为进一步提高LAK疗法的疗效,我们将甲氰咪胍与LAK细胞联合应用来研究对小鼠黑色素瘤及其肺转移的影响。结果证明二者联合应用有更好的抗肿瘤抗转移作用。我们观察了甲氰咪胍(10^-5M)及rIL-2诱导的淋巴细胞毒活性（见附图）,结果表明甲氰咪胍单独应用几更多还原

【Abstract】 We studied antitumor effects of cimetidine（CIM） plus LAK cells. The results showed. （1）In vitro, LAK activity was markedly increased with CIM (10^-5M)and rIL 2（500u/ml） compared to rIL-2 alone. （2）In vivo, the pulmonary melanoma metastasis in C57BL/6 mice was significantly reduced by CIM plus LAK cells compared to LAK alone. The data suggested that there was synergism between CIM and LAK cells on antitumor and antimetastasis.更多还原