【摘要】 作者以蚕沙提取制得脱镁叶绿酸a,加锌盐合成锌叶绿酸a配合物,这在国内外尚属首创。小鼠急性毒性试验结果表明,本品毒性小,LD₅₀为324±40mg/kg。初步临床试用结果表明,本品有较好的生物活性,能消炎防痛、促进肉芽组织生成和上皮组织修复,对切口感染、口腔粘膜溃疡和浅度烧伤有明显疗效,值得深入研究。更多还原

【Abstract】 A method for synthesis of zinc chlo-rophyllin a （Ⅰ）, a promisimg drug forclinical application, is presented. Takingsilkworm faeces as a raw material. chlo-rophyll was extracted with ethyl alcohol.After concentration the solid formed wasdissolved in petroleum ether and the solu-tion was subjected to column chromato-graphy to separate pheophytin a and chl-orophyll a. The products were dissolvedin ethyl ether and the Mg in the productswas stripped off with concentrated hydro-chloric acid,The excess hydrochloric acidin the solution was neutralized with am-monia solution and the mixture washydrolyzed with diluted hydrochloric acidto obtain pheophorbide a.then （Ⅰ） wassyn thesized with pheophorbide a and zincsalt. Th6 characteristics of （Ⅰ） and pheo-phorbide a were checked by IR. UV andelemental analyses. All results of pheo-phorbide a coincided with those values re-ported in literature. The acute toxicityof （Ⅰ） was tested in mice and the LD₅₀of （Ⅰ） was 324±40mg/kg. （Ⅰ） has beenapplied jn several hospitals for severalmonths.It has been found that （Ⅰ） hasoutstanding effects on burns and oral sep-sis and that it increases the growth ofgranulation tissue and epithelium remark-ably.更多还原