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重症肌无力患者T细胞亚群的测定

Evaluation of T Cell Subsets in Myasthenia Gravis by Anti-T Cell Monoclonal Antibodies

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【作者】 周鸣生陈平龚其美徐文桢

【Author】 Zhou Mingsheng;Chen Ping;Gong Qimei;Xu Wenzhen Department of Microbiology and Immunology Researcy Unit Neuropathic Disease

【机构】 华西医大微生物学免疫学教研室华西医大神经疾病研究室

【摘要】 作者采用改良的微量细胞毒试验,应用OKT单克隆抗体系统,对46例重症肌无力(MG)病人和36例健康人外周血中T细胞亚群进行了检测。结果表明,MG患者的OKT3+、OKT4+、OKT3+细胞百分率显著低于对照组,而OKT4/OKT3的比值显著高于对照组(P<0.05)。患者不同性别、年龄、病情及是否用激素治疗,其结果均无显著差异(P>0.05)。

【Abstract】 In this paper, T lymphocyte subsetswere measured in the peripheral blood of46 patients with myasthenia gravis (MG)and 86 healthy controls, by using a modi-fied microcytotoxicity assay and OKTmonoclonal antibodies. The results Showedthat the OKT3+, OKT4+, OKT5+ cells ofthe patients with MG docreased signifi-cantly as oompared with those of the con-trols (57.71% versus 66.42%; 34.50% versus41.65%; 21.23% versus 27.19% respectively,P<0.01), and the OKT4/OKT3 ratio in-creased significantly(2.19 versus 1.64, P<0.05). Furthermore, the patients withthe ocular type had less OKT3+ cells thanthoses with the general type (14.19% versus23.47%, P<0.05 and had a high OKT4/OKTratio(3.27 versus 1.57, P<0.01). No correlating changes of T cell subsetswith clinical conditions in that age, sex,and severity showed, and also that therewas no difference between the patientswhether prednisone was used or not(P>0. 05).

【基金】 国家自然科学基金~~
  • 【被引频次】12
  • 【下载频次】16
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