【摘要】 作者采用改良的微量细胞毒试验,应用OKT单克隆抗体系统,对46例重症肌无力（MG）病人和36例健康人外周血中T细胞亚群进行了检测。结果表明,MG患者的OKT₃⁺、OKT₄⁺、OKT₃⁺细胞百分率显著低于对照组,而OKT₄/OKT₃的比值显著高于对照组（P<0.05）。患者不同性别、年龄、病情及是否用激素治疗,其结果均无显著差异（P>0.05）。更多还原

【Abstract】 In this paper, T lymphocyte subsetswere measured in the peripheral blood of46 patients with myasthenia gravis （MG）and 86 healthy controls, by using a modi-fied microcytotoxicity assay and OKTmonoclonal antibodies. The results Showedthat the OKT₃⁺, OKT₄⁺, OKT₅⁺ cells ofthe patients with MG docreased signifi-cantly as oompared with those of the con-trols （57.71％ versus 66.42％; 34.50％ versus41.65％; 21.23％ versus 27.19％ respectively,P<0.01）, and the OKT₄/OKT₃ ratio in-creased significantly（2.19 versus 1.64, P<0.05）. Furthermore, the patients withthe ocular type had less OKT₃⁺ cells thanthoses with the general type (14.19％ versus23.47％, P<0.05 and had a high OKT₄/OKT_ratio（3.27 versus 1.57, P<0.01）. No correlating changes of T cell subsetswith clinical conditions in that age, sex,and severity showed, and also that therewas no difference between the patientswhether prednisone was used or not（P>0. 05）.更多还原