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硝苯啶和硫氮酮对家兔动脉粥样硬化的影响

The effect of nifedipine and diltiazem on atherosclerosis in cholesterol--fed rabbits

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【作者】 张永珍阎西艴张延荣魏太星党瑜华彭少良钟秀梅王诗瑾燕桂香

【Author】 Zhang Yongzhen;Yan Xifu;Zhang Yanrong;Wei ?aixing;Dang Yuhua;Peng Shaoliang;Zong;Xumei;Wang Shijin;Yan Gueixiang Department of Internal Medicine, The First Affiliated Hospital Department of Laboratory, The First Affiliated Hospital

【机构】 河南医科大学第一附属医院内科河南医科大学第一附属医院检验科河南医科大学第一附属医院检验科

【摘要】 观察硝苯啶和硫氮酮对慢性食饵性高脂血症兔动脉粥样硬化(AS)形成的影响。结果两种药物均明显减轻AS斑块的严重程度.明显降低胆固醇诱致的血浆过氧化脂质(LPO)升高和主动脉内中膜TC和钙含量,硝苯啶亦显著升高血清HDL2-ch水平,降低主动脉内中膜磷脂含量:提示影响Ca++活动的药物可以有效地防治AS形成.并为Ca++代谢异常导致LPO代谢障碍、TXA2-PGI2失衡提供了有力证据。

【Abstract】 The effects of nifedipine and diltiazem on ather lerosis in chronichypercholesterolemic rabbits were studied. The results showed that both nifedi-pine and diltiazem reduced significantly the severity of atheroscleroic plaques,the levels of the cholesterol-induced lipid peroxide, and the contents of thecholesterol and the calcium in the intima of the aorta. Nifedipine also increased significantly the level of HDL2-cholesterol in the serum and reduced thecontents of phospholipid of the intima of the aorta. It is demonstrated thecalcium antagonists are useful to prevent and treat atherosclerosis. These resultsprovide a powerful evidence for the metabolic abnormality of lipid peroxide andthe TXA2-PGI2 imbalance caused dy calcium metabolic abnormality.

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