【摘要】 观察硝苯啶和硫氮酮对慢性食饵性高脂血症兔动脉粥样硬化（AS）形成的影响。结果两种药物均明显减轻AS斑块的严重程度.明显降低胆固醇诱致的血浆过氧化脂质（LPO）升高和主动脉内中膜TC和钙含量,硝苯啶亦显著升高血清HDL2-ch水平,降低主动脉内中膜磷脂含量:提示影响Ca⁺⁺活动的药物可以有效地防治AS形成.并为Ca⁺⁺代谢异常导致LPO代谢障碍、TXA₂-PGI₂失衡提供了有力证据。更多还原

【Abstract】 The effects of nifedipine and diltiazem on ather lerosis in chronichypercholesterolemic rabbits were studied. The results showed that both nifedi-pine and diltiazem reduced significantly the severity of atheroscleroic plaques,the levels of the cholesterol-induced lipid peroxide, and the contents of thecholesterol and the calcium in the intima of the aorta. Nifedipine also increased significantly the level of HDL₂-cholesterol in the serum and reduced thecontents of phospholipid of the intima of the aorta. It is demonstrated thecalcium antagonists are useful to prevent and treat atherosclerosis. These resultsprovide a powerful evidence for the metabolic abnormality of lipid peroxide andthe TXA₂-PGI₂ imbalance caused dy calcium metabolic abnormality.更多还原