【摘要】 本文采用氚离子束标记法,对茯苓聚糖进行了标记,放射性比活性达1.81—2.07TBq/mmol。药物动力学研究证明~3H-茯苓聚糖尿素液口服灌喂小白鼠,按一定时间在尾部静脉取血样作放射性分析。得到的药-时曲线适合于双定模型。更多还原

【Abstract】 In this paper, we discribe technique--Ion beam tritium labelling method for thepreparation of tritium compounds and its use in the tritiation of pachyman. After removal of readlylabile tritium, the tritiated product was obtained with a specific radioactivity of (1.81-2.07TBq/mmol).The pharmacokinetics study was done in mice using 3H-pachyman urea solution. The blood concentration - time curve obtained after p. o. of 3H-pachyman was shown to fit a two compartment open model.更多还原