【摘要】 通过给雄性 Sprague Dawley 成年大鼠(体重280～320g)α-氯丙二醇(20mg/kg/日)使其不孕的同时进行了附睾的组织化学研究,结果发现于停药后1～21天,附睾头、体部的 ACP 活性增高,而 PAS 反应减弱,RNA 含量减少;附睾尾及附睾精子未见此种变化。停药21天后上述变化都逐渐恢复正常,结果提示,α-氯丙二醇干扰大鼠附睾头及体部的上皮细胞的生理代谢。α-氯丙二醇引起的抗生育作用,可能由于精子在附睾进一步成熟的适宜微环境受到破坏,从而使精子丧失受精能力。更多还原

【Abstract】 When the fertility of adult male rats(Sprague Dawley)was controlled with a dose 20 mg/kg/d of α-chlorohydrin for 5 days, the epididymis of the rats were moved out for histochemical studies. From 1 through 21 days after treatment,the activity of acid phosphatese increased while the PAS-posi- tive material and ribonucleic acid content decreased. All of the changes only occurred in the head and body of epididymis. There were no changes found in the tail of epididymis and in the spermatozoa which were present in the epididymis. These data suggest that the effect of α-cholorohydrin on antifer- tility is carried out by doing damage to function of epithelium of the head and body of epididymis.更多还原