【摘要】 本文提出了测定抗精神病新药氯氮平的碳糊电极开路富集/介质交换/溶出伏安法模式,该药物在0.45 V附近显示了氧化溶出峰,在1×10^-6～1×10^-8g/mL范围内峰电流与浓度成线性关系,检测限为4×10^-9g/mL,比紫外光度法提高约100倍。研究表明,碳糊电极对该药物具有强烈的萃取和吸附作用,并且萃取在富集过程中起着主要的作用。该法具有很强的抗干扰能力,可以直接测定片剂和尿样中的药物含量。更多还原

【Abstract】 This paper reports differential pulse stripping voltammetry for determining clozapine, an an-tipsychotic drug, at carbon paste electrodes. Clozapine exhibits an anodic peak at 0. 45 V (vs Ag-AgCl). The response is linear at the range of 1× 10-6-1× 10-8 g/mL with a detection limit of 4×10-9 g/mL. It is demonstrated that the adsorption and extraction play an important role during preconcentration. The ratio of these two parts is evaluated by chronocoulpmetry. The open circuit accumulation/medium exchange/ stripping voltammetry scheme is used to measure clozapine in tablets and urine sample without pretreatment.更多还原