【摘要】 用粘液组化和4种肽类激素抗血清免疫酶组化方法,发现80例女性生殖系统病变中有胃肠型上皮灶者22例(占27.5％),粘液染色显示有胃肠粘液分泌者42例(占52.5％),嗜银及免疫组化染色显示有嗜银细咆及胃泌素、生长抑素、P物质或5-羟色胺阳性的神经内分泌细胞者25例(占31.3％),其中宫颈和宫内膜癌最多占(13例),证实女性生殖系统病变中,内外分泌型细胞在形态和功能上与胃肠道粘膜相似。同时证明恶性病变中神经内分泌型细胞增多,这对宫颈和宫内膜癌早诊及对交界性卵巢粘液性囊腺瘤鉴别诊断有一定价值。更多还原

【Abstract】 Eighty pateints with benign and malignant lesions in female genital tract were studied for mucinand immuno histochemistry. Patchy distribution of gastrointestinal type cells were identified in 22 (27.5％) of the cases; with cells positive for mucins secretory in 42(52.5％), and cells of neuroendocrine (NE) type with argyrophil, gastrin, somatostatin, 5-HT and P substance in 25 (31.3％). Among the 25 cases there was a high frequency with NE cells in adenocarcinomas of the uterus and the endocervial epithelium (13 cases). The findings suggested that the cells of intestinal and NE type in the lesions of female genital tract were identical with the epithelium of the gastrointestinal tract in morphology as well as in functions. This identity may be relevant to the histogenesis of both. The results also demonstrate the likelihood that proliferation of NE cells in the female genital tract are manifestation of malignant or premalignant change.更多还原