【摘要】 用克山病病区粮喂饲大鼠50天左右,用亚硝酸钠急性中毒的方法造成大鼠心肌损伤,同时测定大鼠全血和心肌GSH—P_x活性。结果表明,随着亚硝酸钠给药量的增加,大鼠全血和心肌GSH—P_x活性出现了从代偿到失代偿的变化。提示我们,亚硝酸盐可能是引起克山病心肌坏死缺氧因素中最重要的一个。更多还原

【Abstract】 By gavage of NaNO₂, the myocardial necrosis in the rate fed with the grains cultivated in Keshan-disease endemic area was induced Moreover GSH-Px activity of blood and myocarduim in these rate showed changs from compensation to broken compensation because of increasing in NaNO₂ dosis It. is suggested that excess nitrite could be the one of the most important factors resulting in the ischmic or anoxic necrosis in the myocardium of Keshan-disease.更多还原