【摘要】 本文报告了12对原发性肝癌(PHC)和癌旁组织HBV存在状态的研究结果。在11/12(91.5％)的PHC和9/12(75％)的癌旁组织有HBV DNA整合。整合没有特异性的位点。在2例癌旁组织有单纯游离型的HBV,而相应的PHC中却有HBV DNA的整合,提示HBV整合与PHC发生之间有一定的关系。PHC中整合HBV DNA的量多于癌旁组织,表明是克隆选择作用的结果。在4例病人肝组织内,检测到缺陷型游离HBV,虽然能够在肝内复制,但不能释放入血中。本文同时讨论了HBV整合在PHC发生中的作用。更多还原

【Abstract】 The present paper reports on the study of HBV states in human primary hepatocellular carcinoma (PHC) and tumor-adjacent tissues. The results showed that in 11/12 PHC (91.5%) and 9/12 tumor-adjacent tissues (75%) there were integrated forms of HBV DNA. The amount of HBV integrated in PHC was higher than that in tumor-adjacent tissues, indicating a clonal selection for liver cells containing integrated HBV during the malignant transformation of PHC. In two tumor-adjacent tissues only free HBV was found, while in the corresponding PHCs there was integrated HBV DNA. This suggests that integration had taken place in the process of carcinogenesis of PHC. It was also observed in this study that four patients had putatively defective HBV in their liver cells which could be replicated but not be secreted into serum. The possible role of HBV in the carcinogenesis of PHC is discussed更多还原