【摘要】 用不同pH和浓度的丁卡因溶液喉部表面麻醉临床观察150例。pH7.4浓度0.5％与pH4.8浓度分别为0.5％和2％丁卡因溶液进行了比较，其有效量前者为28.2±8.9mg，后两者分别为54.9±13.1和123.8±48.8mg；手术全程时间为17.5±6.2、28.4±8.3和23.4±10.3分钟；手术成功率为100％、80％和88％；前者手术前后心率升高不明显，提示副作用较小，后两者均有明显升高。结果表明，提高丁卡因溶液pH，使麻醉用量减少，效果加强，安全性提高，值得临床推广试用。更多还原

【Abstract】 Various pH and concentration of tetracaine solution have been compared in clinical larynx surface anesthesia. The anesthetic dosage of tetracaine of pH 7.4 and 0.5% solution was compared to dosages of pH 4.8 and 0.5% or 2 % solution in 150 cases. The former effctive dosage was 28.2±8.9mg, and the latter dosage was 54.9 ± 13.1 and 123.8 ± 48.8mg respectively. Under the former anesthesia the operative time was 17.5±6.2 min; and the latter times were prolonged to 28.4 ± 8.3 and 23.4±10.3 min. The former operative successful rate was 100%, but the latters only 80% and 88%. The former heart rate in before and after operation was unchange, but the latters were increased significantly. The results that tetracaine solution rise pH from 4.8 to 7.4 may enhance anaesthetic action and can decrease the used dosage, so that tetracaine anasthe-tic safety was increased, we suggest that the pH 7.4 tetracaine solution should be instead of pH 4.8 used in clinical practice for surface anaesthsia.更多还原