【摘要】 1987年2～8月,山东省招远县发生一起不明病因的无菌性脑膜炎流行,全县有2646人发病.病死3人。从收集的22人份粪便中分离到3株病毒,经鉴定为耐酸的RNA型病毒.检测13例患者的双份血清,恢复期血清对该病毒中和抗体呈4倍以上升高者5例,抗体阳转者2例,抗体呈4倍降低者1例.经血清学定型该病毒为ECHO29和ECHO2型双重抗原性的病毒。更多还原

【Abstract】 An epidemic of meningitis occurred in Zhaoyuan county Shandong Province in February to August 1987. During the period, about 2, 646 in 550,201 peoples of this county were ill,and 3 patients died. 75% of the patients were at the age of 7-15 years. During the meningitis epidemic period, the isolation rate of virus was 13.6%), 61% of the patients’ paired sera had antibody rise over 4 folds or become sero-converted.3 strains of virus were isolated from 22 fecal specimens by inoculation of primary human embryonic kidney cell cultures.The strains had the same biological characteristics, being resistant to acid at pH 3.0, not sensitive to BUDR, not pathogenetic to babymice. Paired sera of 13 patients were collected, about 61% of the patients had more than 4 folds rise of antibody or became sero-converted.The 3 strains were neutralized by ECH029 and ECHO2 type antisera; and the results of the neutralization test were the same after being treated three time by ECHO2 or 29 type antiserum respectively or after three plaque purifications. The data confirmed that the epidemic-strains are anti-genically related to prototypes ECH029 and ECH02,but were more related to ECHO29. No crossreactivity were found between the prototype strains of ECHO29 and ECHO2.更多还原