【摘要】 本文按IUPAC化学结构分组法,将动物致癌性数据库资料分为13个组,分别评价了17种重要遗传毒理学试验对不同化学结构组别的预测致癌性的可靠性。分析表明,遗传毒理学试验对各化学结构分组的预测可靠性值是不同的。本文推荐了对各化学结构分组预测致癌物优先选择的遗传毒理学试验。更多还原

【Abstract】 Usng the IUPAC preferential ordering scheme, each compound of animal carcinogenicity data base was placed into 13 classes respectively.The validation of 17 genotoxicity tests as predictors of animal carcinogenicity for each chmical class was evaluated. The analysis showed the validation values veried with chemical class. The preferal choices of genotoxicity tests for specific chemical class were recommended .更多还原