【摘要】 根据中医脾胃理论,对健脾益气方进行了临床观察和实验研究。结果发现,中医辨证为脾气虚证的慢性胃病、消化性溃疡84例,慢性肾小球肾炎44例及孕吐、妊娠水肿40例患者,服用健脾益气方后的症状及某些实验室检查指标均有不同程度的改善,总有效率分别为92.9%、86.3%和100%。动物实验研究表明,健脾益气方可以明显抑制豚鼠离体回肠或回肠纵行肌条标本被电刺激引起的兴奋现象,并可抑制乙酰胆碱自奥氏神经丛的释放。更多还原

【Abstract】 According to"Spleen-Stomach"theory,the effect of Jianpi Yiqi prescription(JPYQ)was observed clinically and studied experimentally.168 cases manifested as Spleen-Qi(气)deficiency including chronic gastritis and peptic ulcer(84 cases),chronic glomerulonephritis(44 cases)and vomitus gravidarum-edema of pregnancy(40 cases)were treated with JPYQ.Estimation were made based on their clinical conditions.Serum gastrin,serum cholylglycine,brood acetylcholine and cholinesterase.blood 5-HT and histamine were measured before and after treatment.The overall effective rate was 92.9% in gastritis and peptic ulcer group,86.3% in nephritis group and 100% in pregnancy group respectively. A marked increase of serum glycocholic acid level was shown in gastritis and peptic ulcer and vomitus gravidarum groups.That was considered as the result of the secretion of cholic acid by this prescription.Clinical improvement was also obtained in nephritis group accompanying disappear. ance of albuminuria in 36.4%.Blood level of 5-HT and histamine lowered to Some extent and tended to be normal.Besides,this prescription markedly inhibited electric stimulated excitement on isolated longitudinal muscle strip of guinea pig’s ileum.The mechanism could be the inhibition of release of acetylcholine from Auerbach’s plexus by this prescription.更多还原