【摘要】 <正> 卵巢癌为妇科常见肿瘤之一,但其病因还不甚清楚,为了探讨卵巢癌的危险因素,于1984～1986年在上海市区进行了一次基于全人群的病例一对照研究。 材料与方法 研究的病例为1984.9.1～1986.6.30日期间新诊断的年龄在18～70岁之间上海市区户口的卵巢癌病例。共收集了258例。完成访问229例更多还原

【Abstract】 A case-control study of 229 ovarian cancer cases and 229 population based controlswas conducted during 1984-1986 in Shanghai. This study revealed that nulliparity wasassociated with elevated risk (OR=1.9, 95% .OI=1.0 - 3.6). The protective effect ofparity was positively related to number of livebirths (P<0. 01 ). Tubosterilization andIUD applied were associated with40-50%reduction in risk,with further decrease in riskfor those sterilized many years prior to diagnosis. A history of ovarian cyst was asso-ciated with significantly elevated OR of 6. 3 (95% CI = 2. 1- 19. 0). A dose-dependentrelationship was observed for cigarette smoking with postmenopausal women beingprimarily affected. More cancer cases than controls reported a family history of cancerwith reproductive cancer prodominated. Occupational exposure to paint was related toa 2. 6-fold elevation in risk (95% CI = 1. 1 - 6. 1), no other occupational exposuresshowed any affect.更多还原