【摘要】 在清醒正常血压大鼠,iv Isorhy 2.5mg/kg对BP及HR均无明显的影响,iv 5.0mg/kg则使DAP、MAP和HR降低,但SAP下降不显著,剂量加大至10.0mg/kg时,上述各项指标均明显降低。经十二指肠内给Isorhy 10.0mg/kg后20min出现BP及HR下降,而20.mg/kg剂量组于10min见BP及HR的进一步降低。lsorhy(10.0mg/kg和2.0mg/kgiv)亦能分别显著降低肾性高血压大鼠和麻醉犬的BP和HR。icv Isorhy表明中枢不是其降压作用的主要部位。在体条件下无α受体阻断和神经节阻断作用。本文提示外周阻力下降为其主要降压机制,但负性频率作用也可能有关。更多还原

【Abstract】 The hypotensive effect of Isorhynchophylline(isorhy) was studied in conscious normatensive and hypertensive rats. Isorhy in dose 2. 5mg/kg was effectless on Bp; 5.0mg/kg iv lowered DAP、MAP and HR,but SAP no-statistically significant change; in dose of 10.0mg/kg iv,a marked decrease in the SAP、DAP、MAP and HR was odserved. Isorhy administered by duodenum at doses of 10.0mg/kg and 20.0mg/kg produced a hypotensive effect at 20 min and 10min respectively after medication,and both persisted for more than 3hrs. in rats rendered hypertensive by renal constriction or aneasthetic dogs,the BP and HR were also reduced by Isorhy 10.0mg/kg and 2.0mg/kg by intravenous injection. The fall in BP was unobserved by intra-cerebral ventricle injection (icv) Isorhy 0.2mg/kg,and a transient hypotendive effect was observed by icy isorhy 0.4mg/kg. Isorhy(2.0mg/kg,iv) can’t block the decrease of HR and third eyelid constriction induced by stimulating vagal peripheral and central end ,and antagonize pressor response by iv NA(2.5μg/kg).更多还原