【摘要】 从雷公藤总甙（TII）中分离出五个三萜化合物,T₁,T₂,T₃,T₆,T₂8.除T₁未经药理试验外,其他四个化合物均具有抗炎作用。经波谱和其他理化常数分析,其中T,T₆,T₂8三个化合物再经X-Ray单品衍射结构分析,确证了它们的分子结构,T_?为雷公藤内酯甲;T₂为3β,22β-二羟基-△¹²-齐墩果烯-29-羧酸,是一个新的化合物,命名为雷公藤三萜酸B;T₃为雷公藤三萜酸A;T₆为木栓烷类的Orthosphenic acid;T₂₈为3β.22α-二羟基-△¹²-乌索烯-30-羧酸,命名为雷公藤三萜酸C.更多还原

【Abstract】 Five triterpenoids were isolated from total Glucosides of Tripterygium Wilfordii (TⅡ). TⅠ -was identified as wilforlide A; T2 a new triterpenic acid, as 3β-Ⅱβ-dihydroxy-△12-oleanen-29-oic acid, named Triptotriterpenic acid B; T6 as orthosphenic acid; Ts and T28 had been reported in other papers. T2, T6 and T28 have been further confirmed by X-Ray analysis.All of them were shown to have anti-inflammatory action except T1 wasn’t examined.更多还原