【摘要】 本文报告了对先天性中枢神经系统结构畸形儿进行了有关致病因子的病例对照研究。经单因素和Logistic回归分析表明,产妇在孕初3个月发热、接触有害化学物质、孕期接触以噪声和高温为主的有害物理因素及婴儿父亲饮酒等因素有显著性意义。为防制婴儿中枢神经系统结构畸形提供了依据。更多还原

【Abstract】 The study was carried out in four hospitals in Harbin,from October 1, 1986 to August 31 1987. By means of 1:2 matched case contrl stoudy we surveyed 38 cases of congenital malformations of central nervous system (CMCNS) and 76 controls. 28 risk factors were analysed by methods of monofactorial analysis and Logistic regression analysis. It was found that 10 risk factors had a close relationship with CMCNS (x~2>3.84, P<0.05). And the results of conditional Logistic regression analysis showed that maternal hyperpyrexia (G=16.080, P<0.01, RR=7.2396) contact with poisonous chemical substances (G=1.1662, P<0.01, RR=7.2396) in the first trimester,contact with the harmful physicalel ements during pregnancy (G=6.00., P<0.05, RR=5.7703) and father drinking(G=5.804,P<0.05,RR=7.2563) were the risk factors of CMCNS, It can be thought that in order to prevent CMCNS should be place focus on the prevention of the above four factors.更多还原