【摘要】 18例未治或复发ANLL,2例慢粒急变及10例完全缓解(CR)的ANLL患者作L-CFU,CFU-E及CFU-GM骨髓体外造血祖细胞培养。ANLL未治和复发组的L-CFU、CFU-E及CFU-GM集落数与正常对照有非常显著差异。ANLL的CR组,CFU-E和CFU-GM恢复正常,但L-CFU仍较正常对照组明显多,提示CR后,骨髓中仍残留有白血病细胞。初步认为PHA-MNCCM作为L-CFU的生长因子,有助于CR后ANLL残留白血病细胞检测意义。更多还原

【Abstract】 L-CFU, CFU-E, and CFU-GM bone marrow cell cultures were performed in 18 untreated of relapsed ANLL, 2 CML with blastic crises and 10 ANLL in CR. There were significant differences in plating efficiency (PE) of L-CFU, CFU-E, and CFU-GM between the control and research groups. L-CFU of CR ANLL were still higher than the control, indicating that there were residual leukemic cells in the bone marrow at CR. We preliminarily suggest that PHA-MNCCM has higher specificity for L-CFU growth than PHA-LCM and it might be useful to detect leukemic cells in patients at CR.更多还原