【摘要】 对76例更年期功能性子宫出血(功血)患者测定官内膜胞浆雌激素受体(ER)及孕激素受体(PR)含量,结果增殖症明显高于其它功血组。16例增殖症炔诺酮治疗前后ER、PR含量观察,有效者与无效者变化不同。提示更年期功血测定ER、PR含量可较准确反映卵巢激素对宫内膜的影响及内膜对激素的反应状态;孕激素治疗增殖症时,组织学变化与受体含量变化有关;治疗前ER、PR含量可能预测对孕激素治疗的反应。更多还原

【Abstract】 Endometrial cytosol estrogen receptor (ER) and progesterone receptor (PR) were measured in 7G premenopausal women with DUB. The highest levels of ER and PR were found in endometrial hyperplasia, followed by proliferative which resembles that of mixed pattern. But they were relatively lower in secretory pattern as compared with other groups. Sixteen patients with endometrial hyperplasia were treated with norethindrone for 3 cycles. Thirteen patients who demostrated good response had a markly decrease in ER and PR. There were no significant changes in the remaining 3 who showed no response. Before treatment, higher levels of both ER and PR were observed in patients with good response. Endometral ER and PR could be more accurately reflected the effect of ovarian hormones and the responsive status of endometrium in premenopausal women with DUB. Determination of ER and PR is likely to be useful in predicting the responsiveness of treatment with progestin.更多还原