【摘要】 通过免疫细胞化学方法,采用五种抗体对26例涎腺多形性腺瘤的细胞类型进行研究,并结合文献对该肿瘤的组织起源问题进行讨论。结果表明:涎腺多形性腺瘤部分细胞呈导管上皮分化,部分细胞呈肌上皮分化,部分细胞形态较小,可能是较低分化细胞。实验结果与Batsakis提出的具有多向分化潜能的闰管储备细胞起源学说相符。更多还原

【Abstract】 Twenty-six cases diagnosed as pleomorphic adenoma of salivary glands were tested using five-type antibodies. The results demonstrate that all cells of pleomorphic adenoma are positive for keratin. There were three-type cells that showed different staining expression for cytokeretin, S-100 protein and vimentin. The first type of cells, positive for keretin, include inner layer cells of ductlike structure and partial cells of solid structure. The second type of cells, positive for S-100 protein and vimentin, include outer layer cells of ductlike structure, cells in myxoid and chondroid tissues and partial cells of solid structure. The third type of cells, including partial cells of solid structure, were smaller. They were not stained using the above three-type antibodies.Our results agree with the Batsakis’ s theory that pleomorphic adenoma derived from intercalated duct reserve or stem cells which have the potential for multidirectional differentiation.更多还原