【摘要】 植H615肝癌实体瘤的615纯种小鼠,于植瘤后第15天开始每隔5天腹腔注射2ugSe/g体重的亚硒酸钠及示踪剂量⁷⁵Se,给硒6次后处死,通过葡聚糖凝胶层析观察⁷⁵Se在红细胞、肝及瘤细胞胞浆中的分布。结果发现:胞浆中不仅GPX上结合有硒,也存在着其它的含硒蛋白质;营养水平的硒和抑瘤水平的硒在红细胞、肝及瘤胞浆中的分布情况不同;同一水平的硒在植瘤和未植瘤鼠上述胞浆内的分布也不同。并伴有GPX和其它含硒蛋白质改变。这些现象可能与硒的抑瘤作用有联系更多还原

【Abstract】 2 ppm selenium as Na2SeO3 and tracer 75-Se-selenite was administered to 615 mire inoculated with liver solid tumor six times over a 40-day period by ip. iniection. All mice were killed on the 45th day following tumor cell inoculation. The cytosols of RBC, liver and tumor cell were chromatographed on a Sephadex G-150 column separately. The 75-Se cpm,GPX activity and absorbance at 280 (or 540) nm of each collection were determined. The results showed that several Se-containing proteins except GPX exist in the cytosols; There are some differences about distribution of 75-Se in all of the three oytosols between the mice given nutritional or aaticarcinogenic selenium and with or without bearing tumor; The GPX and selenoproteins have also some; significant chauges. It is suggested chat these beh a-viors are probably responsible for this trace element’s anticarcinogenic properties更多还原