【摘要】 本文应用流行病学中病例对照研究方法对144对原发性肝癌病例及其对照作了研究。结果表明,病例组一级亲属中原发性肝癌累积发病率高于对照组(x~2=8.37,P<0.005,RR=17.67)。遗传度为56.8±5.44%。将病例与对照有无肝癌史作为一个因素,对58例有HBV检测数据的肝癌病例及其按1:2配比的116例对照进行分析,其家族肝癌史为有意义变量(Z=2.15,P=0.03,OR=10.85),在向HBsAg等其它影响原发性肝癌发病的因素调整后,肝癌家族史仍有意义(Z=2.05,P=0.04,OR=10.85)。结果表明,遗传因素可能在原发性肝癌发病中起了较重要的作用。更多还原

【Abstract】 A case-control study was made to an- alyze the role of genetic factor in occurfence of primary liver cancer (PLC). 144 matched cases and controls were involved in this study. The results showed that PLC cumulative incidence rate in the first relatives of PLC cases was higher than that of controls (X~2=8.37, P<0.05, RR=17.67). Heritability was calculated as 56.8±5.44%. On the other hand, we took the family history of PLC as a exposure factor and used traditional case-control methods(conditional logistic regression) to analyze the cases and controls having HBV marker detection (58 PLC cases and 116 controls were involved in the analysis with 1: 2 matching). The family history of PLC was a significant variable in the analysis (Z=2.15, P=0.03 OR=10.73). After adjustment for other risk factors, family history of PLC remained significant. According to the results, we infer that the genetic factor may have an important role in the occurrence of PLC.更多还原