【摘要】 本文采用尿蛋白肌酐指数(PCI)研究自身免疫性甲状腺疾病(AITD)中蛋白尿的发生率。PCI>150者为蛋白尿,结果135例AITD患者中蛋白尿发生率为29.6％。2h与24h尿PCI显著正相关,提示2小时尿PCI检测有其实用价值。PCI与甲状腺功能状态、循环免疫复合物及甲状腺抗体水平无关。在AITD中极轻微的免疫复合物性肾小球肾炎很可能是蛋白尿发生的主要原因。更多还原

【Abstract】 The incidence of proteinuria in patients with autoimmune thyroid disease (AITD) was studied using protein creati-nine index (PCI). 135 AITD, 22 non-AITD patients and 23 normal controls were investigated. 2 and 24-hour urine were collected for measuring urine creatinine and protein. The results showed that for all of the 23 controls, PCI was <100 (41±15); 54 cases of AITD (40%), > 100, 40 cases (29.6%), >150; whereas among those of non-AITD, 20 cases<100 (76±20) and not a single case >150. The measurement of the PCI in 2-hour urine has the same value as in 24-hour. PCI is not correlated with thyroid function, circulatory immune complex and thyroid autoantibody liters. It was indicated that the incidence of proteinuria (PCI>150) was 29.6% in patients with AITD. The proteinuria in AITD may be due to immune complex glomerulonephritis.更多还原