【摘要】 本实验以大鼠为对象,采用气管注入法,观察不同剂量煤焦沥青(CTP)诱发大鼠肺癌的强度及其对生物膜损伤,细胞免疫功能和细胞遗传学效应等方面的影响,结果表明:CTP 诱发大鼠肺癌与染毒剂量相关,同时还观察到CTP 可引起大鼠GSH-PX、CAT 活性下降,LPO 作用增强,淋巴细胞数、ANAE 及PN 明显下降,微核检出率明显增高,与对照组相比差异均有统计学意义(P<0.05或0.01).更多还原

【Abstract】 In this experiment,we observed the incidence of lung cancer induced by differentdoses of coal tar pitch(CTP)instilled intratracheally in rats and its damage onbiomembrane,cellular immunity and cell genetics.The result shows that the rate oflung cancer induced by CTP is related to the dose of CTP and the CTP could reducethe GSH-Px,the activity of CAT,the number of lymphocyte,ANAE and PN,andincrease the LPO,the rate of micronucleus.The differences are statistically signifi-cant as compared to that of control groups(P<0.05 or 0.01)更多还原