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家兔实验性心肌缺血前后血浆TXB2、6-Keto-PGF1α含量及其比值的变化
CHANGES OF PLASMA TXB2, 6-KETO-FGF1α LEVELS AND THEIR RATIO IN EXPERIMENTAL MYCCARDIAL ISCHEMIA OF RABBITS
【摘要】 应用放免法测定30只家免冠状动脉前降支结扎前后不同时限和不同程度缺血时血浆TXB2、6-Keto-PGF1α含量及其比值的变化。结果提示,血浆TXB2含量增加是心肌缺血早期的重要病理现象,6-Keto-PGF1α含量增加可能在对抗心肌缺血中起到有益的保护作用。
【Abstract】 The radio-immuncassay (RIA) methed was used for determining the plasma contents of TXB2 and 6-keto-PGF1α, a relative stable metabclites or TXA2 and PGI2, before and after the ligation of the left anterior descending (LAD) at different intervals. The result suggested that the release of TXB2 might be a pathologic apparence in early ischemia phase, the increase of 6-keto-PGF1α might exert benificial effect on the coronary vasculature and myceardium by providing protection against ischemia damage.
【关键词】 实验性心肌缺血;
血栓素A2;
前列环素;
【Key words】 experimental myccardial ischemia; thromboxane A2 (TXA2); prcstacyclin (PGI2);
【Key words】 experimental myccardial ischemia; thromboxane A2 (TXA2); prcstacyclin (PGI2);
- 【文献出处】 中国医科大学学报 ,Journal of China Medical University , 编辑部邮箱 ,1989年02期
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