【摘要】 肝脏线粒体磷酸甘油脱氢酶（α-GPD）对甲状腺激素极为敏感。我们利用这种反应做为反映靶器官的指标。以便了解在不同甲状腺功能状态下,靶器官的变化。结果表明,靶器官的功能随甲状腺功能的增强而增加,并随其下降而减少。T₃和 T₄均影响肝脏α-GPD 活性,但影响程度不一,起主要作用的是 T₃。更多还原

【Abstract】 The liver mitochondrial α-glycerophosphate dehydrogenase（α-GPD）is verysensitive to thyroxines.We utilized NaClO₄,thiouracil and T₃ to induce the hypo-thyroidism and hyperthyroidism of the experimental rats and then measured livermitochondrial α-GPD activity,serum T₃,T₄ level.We want to investigate theperipheral target organ function on these two situation.The results show that the α-GPD activity increases obviously in hyperthyro-idism group and decreases in hypothyroidism group and the function in peripheraltarget organ varies with thyroid function.In compensated hypothyroidism,eventhough serum T₃ level does not change,α-GPD activity decreases with serum T₄level.Both T₃ an T₄ affect peripheral target function,but in different situation,the affected magnitude is not the same.更多还原