【摘要】 本文研究了脂氧酶抑制剂枸橼酸乙胺嗪对狗急性缺氧性肺血管收缩反应的影响。实验结果发现静脉注射枸橼酸乙胺嗪后能明显地抑制血管对缺氧的收缩反应。并且,枸橼酸乙胺嗪对狗缺氧性肺血管收缩反应的抑制作用与其应用后所引起的体动脉压下降和心脏功能受抑制等副作用似无关。从而提示白三烯在狗的缺氧性肺血管收缩反应中可能起介导作用。更多还原

【Abstract】 The effects of diethylcarbamazine citrate (DEC), a lipooxygenase inhibitor, on hypoxic pulmonary vasoconstriction (HPV) in dogs were studied, The results showed that HPV was significantly inhibited after the intravenous administration of DEC, and that the inhibitory effect of DEC on HPV had seemingly no association with the decrease of systemic blood pressure and depression of cardiac function induced by DEC. It is suggested that leukotrienes play a role of mediator in HPV in dogs.更多还原