【摘要】 本文报告了31例健康人血浆中TXB₂与6-Keto-PGF_1α的测定结果。并对51例急性脑梗塞患者血浆中TXB₂、6-Keto-PgF_1α进行了测定,结果表明急梗组病人较对照组血浆TXB₂明显增高P<0.01);而病入血浆中6-Keto-PGF_1α与对照组相比也有明显差异（P<0.01）,TXB₂/6-Keto-PGF_1α比值增大。40—50岁患者,血浆TXB₂含量明显高于同龄对照组（P<0.01）,而6-Keto-PGF_1α含量组间差异不明显。测定结果提示,TXB₂/6-Keto-PGF_1α失衡与脑血栓性梗塞发生有关;在急性脑梗塞发病机制中可能由于TXA₂生成增多,血小板活性增强所致。更多还原

【Abstract】 The peripheral venous plasma levels of TXB₂ and 6-Keto-PGF_1α were determined by radioimmunoassay in 31 control subjectsandand 51 patients with acute cerebral infarction（ACI）.In ACI patients, the plasma TXB₂ levels were significantly higher than those in control subjects （P<0.01）. In ACI patients, the plasma 6-Keto-PGF_1α levels were significantly lower than those in control subjects（P<0.01）. Therefore, the TXB₂/6-Keto-PGF_1α ratios was significantly increased.A significant increase of TXB₂ was found in patients with an age range from 40-50. There was no significant difference in 6-Keto-PGF_1α levels within this age group. Our results may be considered to show that a disturbed balance between TXB₂ and PGI₂ is associated with the development of cerebral thrombotic infarction. These elevations of TXB₂ are consistent with a role for increased platelet activation in the pathogenesis of ACI.更多还原