【摘要】 为了检查川芎嗪注射液对失血性休克的作用,失血性休克家免于输回血后分别静脉输入不同剂量的川芎嗪注射液。结果表明,休克状态下和对照组相较,输入0.1ml/kg的川芎嗪注射液可改善外周血流但不降低血压,减少血管内液外移;输入0.2ml/kg的川芎嗪注射液虽使外周血流有所改善,但使血压降低。更多还原

【Abstract】 In order to examine the effect of tetramethylpyrazine on hemorrhagic shock, three groups of rabbits were bled to BP 40mmHg, maintained for 1 hr and the shed blood was then reinfused. Group 1 was infused with tetramethylpyrazine injection (0.1ml/kg)in normal saline (35ml/kg). Group 2 was infused with 0.2ml/kg tetramethylpyrazine injection in normal saline (35ml/kg). Group 3 was infused with normal saline only. Systemic blood pressure and the blood flow at the end of dorsal aorta were observed and dry/wet weight ratio of lung and gut was measured. The results of three groups were compared with each others. The results showed that infusion of 0.1ml/kg tetramethylpyrazine into hemorrhagic shock rabbit improved peripheral blood flow and did not depress blood pressure, decreased the transfer, of intravascular fluid into interstitial space. Infusion of 0.2ml/kg tetramethylpyrazine depressed systemic blood pressure significantly, although improved peripheral blood flow更多还原