【摘要】 本实验以43例流行性出血热(以下简称流热)患者皮肤活检标本为对象,以正常人皮肤标本为对照,观察了流热患者发热期、低血压休克少尿期和多尿期肥大细胞的变化。肥大细胞形态观察及定量分析都发现,在流热病程的不同阶段,肥大细胞变化有一定规律性。这些现象用统计学处理与对照组比较均有显著差异,并与患者同期体内特异抗体变化相关,因此认为肥大细胞参与了流热的发病过程。更多还原

【Abstract】 Electron microscopic studies were performed on 43 skin biopsies taken from patients aged between 20-55 years suffering from epidemic hemorrhagic fever(EHF).We investigated the mast cells for their participating in the pathological course in EHF. Quantity studies showed that the numbers of mast cell and the ratio of the volume of mast cells particles to the volume of cytoplasma were decreased with the disease course that was correspondent with the morphological findings. It showed that mast cell degrenulation was a general affair in EHF that actively began at the onset and through the disease course.This research provided the morphological evidence for the hypothesis that allergic reaction, which was triggered by EHF virus and could provoke the degrenulation of mast cells, was responsible for microvessels damage early in the disease.更多还原