节点文献

〔¹⁴C〕氨三肼（AT-1902）在小鼠体内的动态观察

OBSERVATION ON THE DISTRIBUTION OF [¹⁴C] AT-1902 IN MICE

推荐 CAJ下载
PDF下载
不支持迅雷等下载工具，请取消加速工具后下载。

【Author】 QD Wang, HY Hua,QT Li, TM Zhang, X Zhang~* and YF Ren~* (Department of Pharmacology,Henan Institute of Medical Sciences,Zhengzhou 450052; *Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031)

【机构】河南省医学科学研究所药理室；河南省肿瘤研究所；中国科学院上海药物研究所；中国科学院上海药物研究所郑州 450052；郑州 450052；上海 200031；上海 200031；

【摘要】 <正> 氨三肼（AT-1902）由中国科学院上海药物研究所合成室合成。经我室实验证明,对多种动物移植性肿瘤有很强的抗肿瘤作用。本文采用整体放射自显影术,研究[¹⁴C]AT-1902在动物体内的分布情况,进一步阐明分布与疗效及毒性之间的关系,为临床合理用药提供依据。更多还原

【Abstract】 Distribution of [¹⁴C] AT-1902 in mice was studied by means of whole body autoradiography. After [¹⁴C] AT-1902 was injected im to mice, radioactivity was rapidly taken up by various organs.The highest radioacti vity was found in kidneys, then the liver, lung, tumor and skin etc. Lowest radioactivity was found in brain. It is suggested that [¹⁴C] AT-1902 may be excreted through the gastrointestinal tract and kidneys.更多还原