【摘要】 本文通过萘普生和咖啡因、烟酰胺、水杨酸等配体紫外光谱的测定,Job连续递变法实验,确定了它们之间的相互作用。其形成物的比值均为1:1。并用紫外分光光度法测定了形成常数,进而推算了热力学函数,推测了其可能的形成机理。更多还原

【Abstract】 The interaction between water insoluble drug naproxen with caffeine, nicotinamide and salicylic acid in aqueous solutions were determined by speetrophotometry. Naproxen was found to form 1:1 molecular complex with these substances. The complex formation constants were determined by spectrophotometry at room temperature.The thermodynamic functions associated with complexation of naproxen-drugs were also evaluated. It may be concluded that the complex formation may be attributed to hydrogen bonding since enthalpy changes were shown to be a few KJ·mol^-1.更多还原