【摘要】 <正> 氨基膦酸是继氨基酸、氨基磺酸后在生物体中发现的第三类氨基酸,它在生物体中的分布、代谢和功能正在进一步研究中。目前人们正积极开展合成各种天然氨基酸的磷类似物——α-氨基烃基膦酸的肽,且巴发现这类合成肽具有重要的生理活性。在膦肽合成中,α-酰更多还原

【Abstract】 A facile one-pot procedure for the preparation of diethyl N-carbobenzyoxy-or N-acetyl-α-aminoalbylphosphonates from the condensation of relevant aldehydes,amides andphosphorus trichloride was described.A tentative reaction mechanism was proposed anddiscussed.The crystal and molecular structure of dietheyl N-acetyl-α-amino-γ-methyl bu- tylphosphonate（g）and by product N-[α-isopropyl-5-methylhexadienyl-（1,3）]-acetamide（h）were determined by X-ray diffraction.The crystal of（g）belongs to a P（?） space groupwith lattice parameters:α=8.688（4）,b=8.990（3）,c=10.309（2）;α=87.89（2）,β=83.63（2）,γ=88.27（3）and the crystal of（h）belongs to Pna 2₁ space group,the latlice parame-ters are α= 9.326（4）,b=14.276（3）,c=9.843（2）.更多还原