【摘要】 <正> 1,3,4-恶二唑衍生物在医药,农药、染料、涂料、高分子合成材料以及有机闪烁体材料等方面有广泛用途。近年来有关合成和生理活性的研究报道甚多。本文选择被淘汰的解热镇痛、去风湿药物更多还原

【Abstract】 Heterocyclization of a series of N-(2-phenyl-4-quinolinecarbonyl)-N＇-aroylhy- drazines (1) under the catalysies of phosphorus oxychloride has been studied. Cyclization of 1 gave the expected cyclic compounds 2-aryl-5-(2-phenyl-4-quinolyl)-1, 3, 4-oxadiazoles (2). While 2, 5-bis (2-phenyl-4-quinolyl)-1, 3, 4-oxadiazoles (3) was the sole product in the case of 1 with N＇-subutitute of 4-pyrinoyl, 2-fluorinebenzoyl, 3-nitrobenzoyl, 2 and 3 exhibited a little inhibiting effect on L7712-Leukemia cell. Also, 1, 2 and 3 possessed some promoting, or inhibiting activity, on growth of plumule of wheat.更多还原