【摘要】 <正> 肿瘤细胞与正常细胞在酶系上存在差别,利用这些差别,chakravarty等设计并合成缬-亮-赖三肽与苯二胺氮芥等抗肿瘤原药结合的抗肿瘤短肽药物,它们的抗肿瘤选择性比苯二胺氮芥等抗肿瘤原药提高5～7倍。我们在前文中报道了5-氟尿嘧啶乙酰(丙酰)二肽和三肽的合成及抗动物肿瘤试验,初步结果表更多还原

【Abstract】 Twenty new dipeptyl 5-fluorouracil-propyl and butyl ester hydrochlorides were prepared from 5-fluorouracil-propyl esters or 5-fluorouracil-butyl esters of amino acids with N-protected amino acid anhydrides. The antitumor activity of five of them were tested agai- nst Ehrlich Ascites Carcinoma in mice, HC1·Phe-Gly-O（CH₂）₃5-fluorouracil and HC1·Val- Leu-O（CH₂）₃5-fluorouracil showed an inhibition ratio of 89.4% and 86.8%, respectively.更多还原