【摘要】 <正> 近年来二氯有机锡(Ⅳ)含双氮配体络合物具有抗肿瘤活性的发现,不仅为人们寻找性能优良的抗癌药物开辟了新途径,而且其合成与结构的研究势必促进有机锡化学的发展。本文报道了2-(2＇-吡啶基)-6-甲苯并噻唑及其二氯·二乙基合锡(Ⅳ)反应产物的谱学表征、晶体结构和抗癌活性筛选的主要结果。更多还原

【Abstract】 The crystal structures of the title compounds have been determined by X-ray anal- ysis on single crystals by an Enraf-Nonius CAD4 diffractometer. For the ligand L, 2-（2′- pyridyl）-6-methylbenzothiazole, C₁₃H₁₀N₂S, monoclinic, P 2₁/n, a=5.719（1）, b=15.383（1）, c=27.444（4）, β=95.68（1）°, Z=4, R=0.034, and complex [SnEt₂CI₂L], C₁₇H₂₀SN₂- SnCl₂, monoclinic, P2₁/c, a=14.755（2）, b=9.447（5）, c=13.835（1）, β=95.29（2）°, Z=4, R=0.067. Structure of L was solved by direct method and structure of [SnEt₂CI₂L] the heavy atom method. The S atom is cyclized either in the free ligand or in the complex which is consistent with the IR and 1^H NMR characterizations. The Sn atom is coordinated by two nitrogen atoms, cis-chlorine and trans-ethyl groups in a highly distorted octahedron with average Sn-N distance of 2.485 .更多还原