【摘要】 为了探讨胚胎中脑黑质或肾上腺髓质移植对一侧黑质损伤的纹状体头端神经元机能活动的影响,本文观察了大鼠一侧黑质破坏前后及移植后,尾核头端的自发电活动和乙酰胆硷(ACh)、阿扑吗啡(Apomorphine)、多巴胺(DA)及β-羟基丁酸钠对尾核单位放电的影响。结果表明:大鼠一侧黑质被破坏后,出现以旋转为主的行为障碍,其受损侧的尾核头端自发电活动明显减弱;在接受同种胚胎中脑或异体肾上腺髓质移植后,大鼠尾核头部自发电活动可恢复到正常水平,对ACh、Apomorphine、DA和β-羟基丁酸钠的反应同正常大鼠。即ACh、Apomorphine显示兴奋作用,而DA,β-羟基丁酸钠则显示抑制效应。提示脑组织和肾上腺髓质移植能有效地改善由于一侧黑质—纹状体通路受损所引起的尾核神经元的机能状态。更多还原

【Abstract】 Behavioral & electrophysiological studies were carried out for inv estigation of the function neurons in nucleus caudatus (N.C) prior to &post embrynic Nigra or adrenal medulla grafted into N .C. The results were as follows: (1) both Acetylcholine(ACh) & Apomorphine injected into the ventrieulus lateralis increased discharge frequency of neurons in N.C;Dopamine injected into the ventriculus lateralis decreased the discharge frequency of neurons in N.C, and so did Natrii hydroxybutyratis.(2) Discharge frequency in N. C was significantly reduced after 6-hydroxydopamine lesions of nigrastriatal pathway developed, and the discharge was recovered to the normal level by embryonic substantia nigra or adrenal medulla being transplanted into N. C in adult "rotation rats".The results indicate that brain transplantation or adrenal medulla graft can improve the function of neurons in the N. C subjected to lesions.更多还原