节点文献
辅酶Q10抗脂质过氧化作用
ANTILIPID-PEROXIDATION EFFECT OF COENZYME Q10
【摘要】 在离体大鼠心肌细胞和人工生物膜脂质体上,CoQ10显著抑制氧自由基发生系统(FeCl2,抗坏血酸)所引起的脂质过氧化物丙二醛增加,其抑制作用呈剂量依赖和时间依赖关系。本结果证实CoQ10具有抗氧化作用,在膜水平上直接起到自由基清除剂样作用。
【Abstract】 In the isolated adult rat’s ventricular myocytes and artificial bio-membrane-liposomes, the lipid peroxidation caused by generating system of free radicals (FeCl2 & ascorbic acid ) was significantly inhibited by Co Q10, and the inhibition effect of Co Q10 was both dose-and time-dependent. The results showed that Co Q10 had an antioxi-dation effect and served as a scavenger of free radicals at the level of membrane .
【基金】 国家“七五”攻关资助项目
- 【文献出处】 中国药理学通报 ,Chinese Pharmacological Bulletin , 编辑部邮箱 ,1989年05期
- 【被引频次】11
- 【下载频次】110