【摘要】 ~3H—小檗碱家兔ig、iv后,血药时程曲线符合二室模型。动力学参数:T1/2β为35.3±1.3h(ig)和35.8±2h(iv),Vd为20±3L/kg(ig)和22.1±1.7L/kg。该药吸收快,分布广泛。肺中浓度最高,其次为肝、脾、肾、心。血浆蛋白结合率为38±3％。大鼠6d内从尿和粪中排泄分别为73％和10.9％。尿液排泄中以原形药物为主,并有代谢产物。更多还原

【Abstract】 After ig and iv 3H-berberine in rabbits, the plasma radioactivity-time cure was found to be 2-compartment open model. The pharma-cokinetic parameters were: T1/2B 35 .3±1 .3h ( ig ) and 35.8 ± 2.0h (iv), Vd 20 ±3 L/kg(ig) & 22.1±1.7 L/kg ( iv ) . 3H-berberine was rapidly absorbed & taken up by various organs . The highest radioactivity was found in lung, followed by liver, spleen & heart. The rate of binding with plasma protein was 38 ± 3 % . In 6 d cumulative excretion of radioactivity was 73% of total dose in urine & 10.9% in fe-ces . 3H-berberine was excreted mainly in unchanged form, as measured by TLC & liquid scintillation counting in urine & bile.更多还原