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~3H-小檗碱在家兔及小鼠体内的药代动力学研究

PHARMACOKINETIC STUDY OF ~3H-BERBERINE IN RABBITS & MOUSE

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【作者】 熊程亿施绪保代宗顺方达超

【Author】 Xiong Chengyi, Shi Xubao & Dai Zongshun et al(Dept. of Pharmacology, Tongji Medical University, Wuhan, 430030)

【机构】 武汉冶金医学专科学校药理教研室北京协和医院核医学科同济医科大学临床药理研究室同济医科大学药理教研室 430080武汉430030

【摘要】 ~3H—小檗碱家兔ig、iv后,血药时程曲线符合二室模型。动力学参数:T1/2β为35.3±1.3h(ig)和35.8±2h(iv),Vd为20±3L/kg(ig)和22.1±1.7L/kg。该药吸收快,分布广泛。肺中浓度最高,其次为肝、脾、肾、心。血浆蛋白结合率为38±3%。大鼠6d内从尿和粪中排泄分别为73%和10.9%。尿液排泄中以原形药物为主,并有代谢产物。

【Abstract】 After ig and iv 3H-berberine in rabbits, the plasma radioactivity-time cure was found to be 2-compartment open model. The pharma-cokinetic parameters were: T1/2B 35 .3±1 .3h ( ig ) and 35.8 ± 2.0h (iv), Vd 20 ±3 L/kg(ig) & 22.1±1.7 L/kg ( iv ) . 3H-berberine was rapidly absorbed & taken up by various organs . The highest radioactivity was found in lung, followed by liver, spleen & heart. The rate of binding with plasma protein was 38 ± 3 % . In 6 d cumulative excretion of radioactivity was 73% of total dose in urine & 10.9% in fe-ces . 3H-berberine was excreted mainly in unchanged form, as measured by TLC & liquid scintillation counting in urine & bile.

【关键词】 小檗碱动力学分布排泄
【Key words】 BerberinePharmacokineticsDistributionExcretion
  • 【文献出处】 中国药理学通报 ,Chinese Pharmacological Bulletin , 编辑部邮箱 ,1989年05期
  • 【被引频次】62
  • 【下载频次】371
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