【摘要】 9名志愿受试者口服利福喷丁(Rifapentine)连续给药10d,随后改为每周两次的间隙给药连续3周的药代动力学研究结果,与利福定作比较。发现利福喷丁吸收、排泄均较利福定慢,在体内维持时间长,T1/2为15h。连服药10d,血中药浓先是逐渐上升,4、5d达到最高,随后下降,这可能与利福霉素激活肝药酶有关。更多还原

【Abstract】 The pharmacokinetic study of Rifapentine by daily oral administration for 10d and followed by twice weekly for another 3 weeks in 9 volunteers and in comparism with Rifandin were reported. The results showed that the absorption and excretion of Rifapentine were markedly slower than that of Rifandin, its T1/2 was 15h. The Peak plasma level and T1/2 decreased after repeated administration of the drug. This suggested that Rifapentine and Rifandin in similar to Ri-fampin were hepatic microsomal enzyme inducers.更多还原