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复方鸭血烯酸钠制剂治疗带状疱疹

Olefinic acid compound prepared from duck blood given topically for the treatment of herpes zoster

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【作者】 钱启源文礼襄杨树青江行娟刘玉顺王建平

【Author】 QIAN Qi-Yuan,YANG Shu-Qing,WEN Li-Xiang, JIANG Xing-Juan, LIU Yu-Shun, WANG Jiaa-Ping (Biomedical Enginnering institute of Fudan University, Shanghai 200433) Institute of Genetics, Fudan University,Shanghai 200433First Affiliated Hospital of Suzhou Medical College,Suzhou 215002

【机构】 上海复旦大学生物医学工程研究所复旦大学遗传学研究所苏州医学院第一附属医院 上海 200433上海 200433

【摘要】 本文介绍鸭血烯酸钠配伍5-氟尿嘧啶(5-FU)软膏涂布治疗带状疱疹25例,对照组17例用5-FU软膏。经过相同时期治疗,治疗组总有效率为96%,对照组总有效率64%,2组差异显著。(P<0.05)。疼痛消失平均时间在治疗组为3.3±2.5d,对照组为8±4d(P<0.01)。在电镜下观察发现治疗后的水痘-带状疱疹病毒包膜变薄,破裂或消失,核衣壳内无DNA病毒。

【Abstract】 Twenty-five patients of herpes zoster were treated topically with olefi-nic acid compound prepared from duck blood (DBOA)and 5-FU,another seventeen patients were treated with 5-FU as control.The total effective rate in the treated group was 96% and in the control group 64%(P<0.05). The pain disappeared after an average of 3.3±2.5 d in the treated group and 8± 4 d in the control group (P<0.001).After treated with DBOA compound, the electronic microscopy show- ed that the envelop of varicella-herpas zoster virus became thin, even brocken and disappeared, and the capsid of virus did not contain viral DNA.

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