【摘要】 应用吡喹酮缓释片治疗230例日本血吸虫病患者,並以吡喹酮普通片236例作对照,按双盲法进行,剂量40mg/kg1次顿服。缓释片的无反应率31.74％,普通片17.7％。两者差异非常显著(p<0.01)。主要副反应头昏、腹痛、恶心,头痛等也以缓释片发生率明显为少,反应程度也轻,治后3个月粪孵阴转率两种剂型无差异(p>0.05)。认为吡喹酮缓释片40mg/kg1次顿服,值得现场推广。更多还原

【Abstract】 230 cases of schistosomiasis japonica were treated with slow-release praziquantel and 236 cases with ordinary praziquantel as control. The total dosage of both drugs was 40 mg/kg in one single dose and the study was completed by double-blind observation. 31.74% of the patients received slow-release praziquantel had no side effects, whereas with the control group, only 17.3%, the difference was statistically significant(p<0.05). The main side effects such as dizzinees, abdominal pain, nausea, headache were less seen in the group received slow-release tablets and were much milder. The negative conversion rates by hatching method of stool 3 months after treatment reveled no statistical significance between the two groups. It is suggested that slow-release tablets with a total dosage of 40mg/kg in one single dose is worthwhile to be used in endemic areas.更多还原