【摘要】 本文报道了用冷冻干燥法制备吡罗昔康β-环糊精包合物,并经差示扫描量热法,红外光谱和X射线衍射光谱证实,体外溶出实验亦进一步确证冷冻干燥法所制得的冻干品为包合物。将吡罗昔康β-环糊精包合物的胶囊以及吡罗昔康昔通片分别给予7只新西兰大白兔,用HPLC法测定血药浓度,结果表明,两种制剂在兔体内的生物利用度没有显著差异。更多还原

【Abstract】 Inclusion compound of piroxicam with β-cyclodextrin (PIR/β-CD) was prepared by freezedrying, and was confirmed by differential scanning calorimetry, infrared spectra, powder X-ray diffractometry and determination dissolution rate. The capsule of PIR/β-CD and the conventional tablet of piroxicam were administration to 7 New Zealand rabbits in a cross-over method, then the piroxicam concentrations in serum were determined by HPLC method. There was no significant difference in bioavailability between two dosage forms.更多还原