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中药全蝎抗肿瘤作用初探 Ⅱ 对癌细胞作用观察和有效成分提取

A PRELIMINARY RESEARCH OF THE ANTINEOPLASTIC EFFECTS INDUCED BY BUTHUS MARTENSII OF CHINESE DRUG Ⅱ. observation of the effect on cancer cells and the extraction of its effective composition

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【作者】 张甫同; 杨建勤; 沈漪涟; 高丽娜;

【Author】 Zhang Futung Yang Jianqin Shen Yilian Gao Lina (Wannan Medical College, Professional Training school of Traditional Chinese Medicine, Wuhu)

【机构】 皖南知学院生理学教研室; 皖南知学院微生物学教研室; 皖南知学院芜湖中医学校; 皖南知学院诊断学教研室;

【摘要】 用全蝎提取物水溶液,对体外传代培养的人体肝癌细胞(BEL—7402细胞)和人体子宫颈癌细胞(HeLa细胞)作观察。结果:全蝎提取物的水溶液在相当生药10mg/ml时,用药48~72小时内使上述细胞全部脱壁死亡。进而在Hela细胞上证明,相当生药0.1mg/ml时也同样作用;並以此为有效标志,查明530号粗提物为全蝎直接抑杀癌细胞的有效部位。

【Abstract】 The effect of water solution of Buthus Martensii (BM)on cultivated human cancer cells of the liver (BEL-7402 cells) and of the cervix (HeLa cells) was observed. All the cells died in 48-72 hours when BM extract solution was used in a concentration of 10mg/ml corresponding with crude drug. And the same effect on HeLa cells was found when the concentration was reduced to 0.1mg/ml.Taking this as the valid sign, we demonstrated that the cancer cells were strangled directly by the effective part of BM in No.530 roughly extracted mateial.

  • 【文献出处】 皖南医学院学报 ,Mcta Academiae Medicinae Wannan , 编辑部邮箱 ,1989年02期
  • 【被引频次】9
  • 【下载频次】128
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