【摘要】 我们以灭活卡介苗(BCG)联合其他药物治疗肾病型的原发性肾小球肾炎(PGN),60例(大部对激素不敏感)中完全和基本缓解者分别为32和16例。对病理类型和临床表现相仿者,BCG 组疗效远胜于对照组。随访1～2年以上的15例中,13例完全缓解。对24例 PGN 病人单核细胞吞噬功能检查的结果表明,PGN 组明显低于正常对照组,经 BCG 接种3周后可使之恢复正常。对家兔改良的慢性血清病肾炎(呈系膜增殖性)模型接种 BCG 的结果显示,BCG 组肾小球炎症明显轻于对照组。以上结果提示 BCG 接种有助于 PGN 的治疗。更多还原

【Abstract】 Since 1984,we have taken a killed BCG as a main measure combined with someother drugs to treat primary glomerulonephritis(PGN)of mainly nephrotic type.Thecomplete and approximate remission of 60 cases(most were insensitive to the corti-costeroid)were 32 and 16 respectively.As to those with similar pathologic and clini-cal findings,the effects were much better in the BCG group than in the controlgroup.Of 15 cases undergoing follow-up over 1～2 years 13 had complete remission.The effects of BCG on the phagocytic function of monocytes in patients withPGN were studied.It was found that this function in the PGN group was significan-tly lower than that in the control group and could be normalized through a 3-weekBCG inoculation.The protective role of BCG in a modified rabbit model of chronic serum sicknessGN mainly with MsPGN were also studied.Our study showed that the circulatoryimmune complex(CIC)level was significantly lower and the mean cell count per glo-merulus was significantly fewer in the BCG treated group than in the control group.These results suggested that BCG inoculation might be of benefit to the treat-ment of PGN.更多还原