【摘要】 选用SD纯系大鼠造成慢性氟中毒,加用复方硼砂片治疗,观察动物中轴骨（椎体）和四肢骨⁴⁵Ca 摄取率的变化以及肝、肾、心肌、腓肠肌几种酶组织化学反应。结果显示慢性氟中毒可促进 F^-、⁴⁵Ca 在骨骼中的沉积、抑制肝、心肌琥珀酸脱氢酶、三磷酸腺苷酶和肝脏6-磷酸葡萄糖脱氢酶的活性。复方硼砂片有拮抗氟毒的效用,可减少 F^-、Ca 在骨骼中的沉积,减轻氟对脏器某些酶活性的抑制作用。提示硼制剂可能影响氟的吸收,并抑制氟对组织的直接毒性作用。更多还原

【Abstract】 Therapeutic dose of Tab.Borax co.was used on animal models of experimentalchronic fluorosis in SD rats to explore the mechanism of its therapeutic effect.Auto-radiography of ⁴⁵Ca was made on the skeletal system to determine the uptake rateof ⁴⁵Ca by the axial skeleton and the extremity skeleton,and,enzyme histochemicalstains were done on the liver,cardiac muscle,kidney and skeletal muscle to studythe toxic effects of fluoride on these organs.The results showed:Borax could inhibitthe deposition of F and Ca in the skeleton and the toxic effect on enzymatic acti-vity in certain organs induced by fluoride.更多还原